The effect of annealing time on microstructure and mechanical properties of TI-6.0 Al-3.0 Zr-0.5 Sn-1.0Mo-1.5 Nb-1.0 V new titanium alloys were studied based on the optimum annealing temperature of 740 ℃. The results show that after three times smelting by vacuum consumable arc furnace and three hot rolling, the microstructure of the plate is the partial recrystallization and the processing status structure composed of the primary α phase and structure of β transformation. The microstructure of the annealed sheet was mainly composed of the primary α phase, the proportion of α phase increased gradually, the proportion of β phase decreased gradually. The strip-shaped α phase in the microstructure was broken and spheroidized gradually, and the size of equiaxial α phase began to be homogenized and coarsened. With the increase of annealing time, the elongation of the sheet increases greatly, while tensile strength decrease first, then increase and then decrease again, the yield strength and the microhardness increases first and then decreases. When the annealing time is 1 h, the fracture mode is ductile fracture and fracture was composed of slip bands, ripples appearance and small equiaxial dimples. When the annealing time is more than 2 h, the fracture mode was ductile fracture and the fracture was completely composed of equiaxial dimples. According to the experimental results, the optimum annealing heat preservation time at 740 ℃ is 2 h, at which time the tensile strength, yield strength, elongation and microhardness of the alloy plate are respectively 984 MPa, 941 MPa, 15.27% and 347.67 HV. The main results from this paper can guide the formulation of the annealing process of high strength corrosion resistant titanium alloy, and provide a scientific basis for solving the problems encountered in the actual production of titanium alloy.