Coarse aggregate paste filling is the core direction of mine development today. To study the pipeline conveying characteristics of tailing-waste rock paste, the rheological properties of the paste were tested by rheometer under different tailing-waste rock ratios and solid content conditions. A resistance equation integrating compactness, water-cement ratio, and volume concentration is constructed. And it was brought into Comsol software for simulations and compared with the actual measurement results of the ring pipe to verify that the errors measured by the numerical model were all within 7%, indicating that the model is reasonable for calculating the resistance characteristics of the tailing-waste rock paste. The variation characteristics of pipeline conveying resistance under different solid content, tailing-waste rock ratio, and initial velocity conditions were also simulated. The experimental results show that the plastic viscosity and yield stress increase with the solid content and the tailing-waste rock ratio. Due to the friction effect between the particles, the resistance loss tends to increase and then decrease with the tailing-waste rock ratio. The increase in solid content leads to a decrease in the water content of the paste, which leads to difficulty in the flow of coarse aggregate slurry and a rapid increase in resistance loss. The initial flow rate increases, the particle motion becomes unstable, friction increases, and the growth rate of drag loss increases greatly after the "inflection point" of 2.2 m·s-1. It is recommended that the mine should be filled with a tailing-waste rock ratio of 5:5 and an initial flow rate of 2.2 m·s-1.