Abstract: Hydrogen production by microwave from biomass is an efficient, rapid and environmentally friendly chemical engineering technology. Lignin is the only renewable aromatic hydrocarbon resource in nature, therefore lignin-based forest biomass is a good raw material for hydrogen production. The factor that restricts the industrialization of hydrogen production by microwave mainly comes from the microwave hot spot effect. This paper carried out the overall modeling design of the reactor based on the penetration depth of biomass under different microwave frequencies, and the working conditions of thermal uniformity and the reactor's height to diameter ratio were obtained by orthogonal design simulation, CFD and HYSYS. Finally, the operating parameters of the maximum hydrogen yield of the 10,000-ton industrial device were obtained through process optimization.