Ceramic membrane is one of the most effective materials for hot flue gas cleaning. Its filtration performance and regeneration performance are related to the deposition and desorption mechanism of dust particles in the channel of ceramic membrane. In this paper, the physical model of ceramic membrane with different porosity is established, and then the boundary conditions and deposition conditions are set up by combining the continuity equation, momentum equation and energy equation to simulate the flow of hot flue gas and the deposition and desorption process of dust particles during ceramic membrane filtration and pulse backblowing. The results show that when the filtration velocity is low and the porosity of ceramic membrane is high, it is easy for dust particles to deposit in the ceramic membrane channel; when increases the back blowing pressure, prolongs the back blowing time during the pulse back blowing, dust particles can easily desorb from the channel of ceramic membrane. When a ceramic membrane tube with a thickness of 20 mm, a length of 1.5 m, a porosity of 40% is used to filtrate the flue gas with a filtration temperature of 1000 ℃, a flow rate of 1 m·min-1 and a pressure of 0.1 MPa, the blowback pressure should not be less than 0.3 MPa, the blowback time should be longer than 0.02 s, and the pulse blowback time interval should be more than 452 s.