With the depletion of easy-to-treat gold ore resources, gold ore containing arsenic, carbon, high sulfur, and ultrafine particles has become the focus of gold mining. These difficult-to-treat gold ores have poor leaching effects through conventional cyanide leaching methods. Chemicals are highly toxic, endanger human health and seriously pollute the ecological environment. In order to achieve efficient and environmentally friendly recovery of gold from refractory gold mines, non-cyanide leaching of refractory gold mines has attracted widespread attention. This article summarizes the methods of non-cyanide leaching of gold: thiosulfate method, glycine method, halide method, lime sulfur mixture method, iodization roasting process, biological oxidation thiourea leaching method, non-aqueous gold leaching method. The gold leaching principles of seven non-cyanide gold leaching methods and the latest research progress in refractory gold mines are introduced. Based on the problems of non-cyanide gold leaching methods such as expensive leaching agent, difficulty in recovering gold in leaching solution, complicated leaching system, unstable properties of leaching agent and large consumption, the development direction of non-cyanide gold leaching technology is prospected.