Abstract: The rapid development of artificial intelligence (AI) has injected new vitality into various industries and provided new ideas for the development of traditional Chinese medicine (TCM). The combination of AI and TCM provides more technical support for TCM auxiliary diagnosis and treatment. In the history of TCM, many methods of syndrome differentiation have been observed, among which the differentiation of Zang-fu organs is one of the important methods. The purpose of this paper is to provide support for the localization of Zang-fu in TCM through AI technology. Localization of Zang-fu organs is a method of determining the location of lesions in such organs and is an important stage in the differentiation of Zang-fu organs in TCM. In this paper, the localization model of TCM Zang-fu organs through the neural network model was established. Through the input of symptom text information, the corresponding Zang-fu label for a lesion could be output to provide support for the realization of Zang-fu syndrome differentiation in TCM-assisted diagnosis and treatment. In this paper, the localization of Zang-fu organs was abstracted as multi-label text classification in natural language processing. Using the medical record data of TCM, a Zang-fu localization model based on pretraining models a lite BERT (ALBERT) and bidirectional gated recurrent unit (Bi-GRU) was proposed. Comparison and ablation experiments finally show that the proposed method is more accurate than multilayer perceptron and the decision tree. Moreover, using an ALBERT pretraining model for text representation effectively improves the accuracy of the localization model. In terms of model parameters, the ALBERT pretraining model greatly reduces the number of model parameters compared with the BERT model and effectively reduces the model size. Finally, the F1-value of the Zang-fu localization model proposed in this paper reaches 0.8013 on the test set, which provided certain support for the TCM auxiliary diagnosis and treatment.