Sensitive materials of sensors for detecting volatile organic compounds (VOCs) play an important role in gas adsorption and selectivity. Therefore, the specific surface area, pore size and functional groups of sensing materials determine the response and sensitivity of sensors. Metal-organic framework (MOF) are characterized by rich porosity, high specific surface area, structural diversity, chemical stability, etc. In addition, some MOF derivatives also have good electrical conductivity, so MOF and its derivatives have been widely used in gas sensors. Chemiresistive sensor has been widely used in many field because of its simple structure and quick analysis. In this review, the basic principle of resistance sensor, the role, principle and application of MOF and MOF derivatives in the detection of volatile organic compounds are summarized, and the development prospect and challenges are also prospected.