Abstract: ODS steel is considered to be an important candidate material for cladding materials for sodium-cooled fast reactors due to its good high-temperature mechanical properties and radiation resistance. In this paper, 15Ni-15Cr ODS austenitic steel was prepared by mechanical alloying, hot isostatic pressing and forging process, and 15Ni-15Cr austenitic steel without oxide was prepared by the same process as the reference material. The microstructure of the sample was analyzed by TEM, and it was found that the grain sizes of 15Ni-15Cr and 15Ni-15Cr ODS austenitic steels were 0.75 μm and 0.5 μm, respectively. The oxide dispersed particles distributed in 15Ni-15Cr ODS austenitic steel are mainly δ-Y4Zr3O12 and a small amount of Al2O3. The average particle size of oxide dispersed particles in 15Ni-15Cr ODS austenitic steel is 12.8 nm and the number density is 5.5× 1022 /m3, the particle spacing is 26 nm. Compared with 15Ni-15Cr austenitic steel, 15Ni-15Cr ODS steel has higher strength but lower plasticity at high temperature.