能反映尘肺病理的肺磁场弛豫参量

The Lung's Magnetic Relaxation Parameter Being Able to Tracing the Pneumoconiosis Pathology

摘要: 在改进弛豫曲线拟合方程为双对数模型的基础上,提出一个能综合反映肺磁场弛豫特性的新参量α^*。通过对一批大剂量染铁硅混合尘的大鼠病理模型进行实验,得到了α^*随染尘后时间τ的变化规律,发现α^*随动物临床死亡后的时间以双曲线规律下降,弛豫α^*值与动物病理切片的评分值呈线性相关。

Abstract: Based on proposing a new equation B=Bo + B_I In (t+1) +B₁₁ 1n² (t + 1) for fitting the relaxation curve, a new relaxation parameter, which can characterize the curve comprehensively, is put forword. Byexperimentally investigating a number of rats exposed to 80 mg SiO₂+20mg Fe₃O₄ particles, the variation law; of α^* vs. the time after exposure &/or death are gained. A highly significant linear negative correlation between the α^* values and the grade data got from the pathologic sections is discovered.