Abstract: In order to study the influence of fluid-solid coupling on the dynamic response of a simplified desulfurization tower structure model,the fluid-solid coupling effects of the model under seismic waves were simulated by using the finite element program Adina.Firstly,the desulfurization tower structure was reasonably simplified,its modal analysis was done at different liquid levels,and the influences of the liquid level on its self-oscillation frequency and vibration mode were analyzed.Secondly,the effects of the liquid level,the input angle and the peak value of earthquake acceleration on the acceleration and displacement of the desulfurization tower were discussed by loading seismic waves and were compared with experimental results.The result shows that the self-oscillation frequency intensifies with the liquid level rising.The liquid level,the input angle and the peak value of earthquake acceleration all have great influence on the acceleration of the desulfurization tower,but they have little effect on the displacement of the desulfurization tower.